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Wernicke–Korsakoff syndrome

Symptoms of Wernicke’s encephalopathy include the following:

O confusion

O loss of muscle coordination (ataxia)

O leg tremor

O vision changes

O abnormal eye movements (back-and-forth movements called nystagmus)

O double vision

O eyelid drooping.

Symptoms of Korsakoff syndrome include the following:

O inability to form new memories

O loss of memory, which can be severe

O making up stories (confabulation)

O seeing or hearing things that are not really there (hallucinations).

Treatment of severe hyperemesis where possible symptoms or signs of Wernicke–Korsakoff syndrome are present

Give an IV infusion of 10 mL of Pabrinex (Vials 1+2) in 100 mL of 0.9% saline over 1 hour (vials contain thiamine, ascorbic acid, nicotinamide, pyridoxine and riboflavin).

Subsequently, give oral thiamine 50 mg three times daily until vomiting has stopped.



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